{"product_id":"sam-e-400-mg-60-tablietki","title":"SAM-e 400 mg - 60 Tablets","description":"\u003cp\u003e\u003cstrong\u003eJarrow Formulas® SAM-e 400\u003c\/strong\u003e – provides a full net amount of 400 mg of SAM-E, derived from 800 mg of SAM-E tosylate disulfate. This product is manufactured according to best manufacturing practices for SAM-E, at low temperature and low humidity, and is enteric coated to ensure a biologically active product. SAM-e has undergone numerous clinical studies involving thousands of patients. Researchers have identified many structural and functional benefits of SAM-e, involving over 40 biochemical processes with a variety of effects on the body, including improved liver function, increased cartilage formation, and improved mood.\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eSAM-E has been clinically proven to have the following benefits:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eJoint Health:\u003c\/strong\u003e SAM-E supports the production of healthy connective tissue through transsulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-E metabolites to produce sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eBrain metabolism:\u003c\/strong\u003e The methylation effects of SAM-E are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, adrenaline, and phosphatidylcholine (a component of lecithin).\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eLiver:\u003c\/strong\u003e SAM-E metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances critically important for liver function, including phase II detoxification.\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eNot all SAM-e products are the same\u003c\/strong\u003e\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eSAM-E\u003c\/strong\u003e exists in two forms: (S,S) SAM-E and (R,S) SAM-E. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive (but widely used in supplements).\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eJarrow Formulas® SAM-e\u003c\/strong\u003e is primarily in its active form. It is naturally produced through microbiological fermentation, then specially processed, without solvents, to retain 68-80% (S,S) SAM-E, the highest active level available.\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eSAM-e\u003c\/strong\u003e is a very fragile and highly reactive molecule. It degrades rapidly at high temperatures or humidity. Improper handling of SAM-e can lead to degradation within a few hours.\u003cbr\u003e \u003cbr\u003eTherefore, Jarrow's technological superiority allows the use of a special method in which production is carried out under conditions of low temperature and low humidity. Each tablet is enteric-coated and blister-packed to ensure the highest possible bioavailability and safety for SAM-e available on the market. Pharmacokinetic studies have shown that taking SAM-e supplements is most effective when an enteric coating of special gastro-resistant fluid polymers is present.\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eHonors and Awards:\u003c\/strong\u003e \u003cstrong\u003eJarrow's SAM-e\u003c\/strong\u003e product is ranked #1 in sales in the natural products channel for 52 weeks, as reported by SPIN, a market research and consulting firm for the Dietary Supplement Industry. Jarrow Formulas was one of the first companies to produce SAM-E, giving the company the most experience in producing this unique product.\u003cbr\u003e\u003cbr\u003e Keep out of the reach of children.\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e 1 tablet daily on an empty stomach or as directed by your qualified healthcare professional.\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e People using prescription medications such as antidepressants, including Selective Serotonin Reuptake Inhibitors (SSRIs) and MAOIs, should consult a physician before using SAM-e. Patients with Parkinson's disease, bipolar disorder, or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed the recommended dosage. In rare cases, it may cause gastrointestinal upset in some individuals. If you experience discomfort, discontinue use.\u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eOther ingredients:\u003c\/strong\u003e Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glycolate, and enteric coating (methacrylate copolymers, magnesium silicate, titanium dioxide, triethyl citrate, silicon dioxide, and riboflavin).\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eDoes not contain:\u003c\/strong\u003e Wheat, soy, gluten, dairy, eggs, fish\/shellfish, peanuts or tree nuts.\u003cbr\u003e\u003cbr\u003e \u003cstrong\u003eJarrow Formulas ® SAM-E 400\u003c\/strong\u003e is packaged in a foil blister pack to maximize stability and safety. Do not use if the outer blister pack is damaged.\u003c\/p\u003e","brand":"Jarrow Formulas","offers":[{"title":"Default Title","offer_id":54428784689496,"sku":"790011200420","price":85.56,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0831\/8989\/1416\/files\/SAM-e-400-mg-60-Jarrow-Formulas-Feel-You-63096762663256.jpg?v=1778235566","url":"https:\/\/nutrabest.eu\/en-mt\/products\/sam-e-400-mg-60-tablietki","provider":"Nutra Best Europe","version":"1.0","type":"link"}